Research status and regulatory mechanism based on supramolecular "imprinted template" of toxicity of Chinese materia medica
10.7501/j.issn.0253-2670.2020.21.030
- VernacularTitle: 中药毒性的研究现状及其超分子“印迹模板”调控机制的探讨
- Author:
Yu-Ting HE
1
Author Information
1. College of Pharmacy, Hunan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Equilibrium constant;
Imprinting interaction;
Network-toxicity kinetics;
Qi chromatography;
Supramolecular chemistry;
Toxicity of Chinese materia medica
- From:
Chinese Traditional and Herbal Drugs
2020;51(21):5638-5644
- CountryChina
- Language:Chinese
-
Abstract:
Based on the universal regularity of the automatic action of supramolecular "imprinted template" previously proposed, this paper further analyzed and summarized the historical evolution and research status of the toxicity of Chinese materia medica, and deeply analyzed the production of toxicity of Chinese materia medica by using the theory of supramolecular chemistry. After entering the human body, the aggregation of supramolecular "imprinted template" of Chinese materia medica can interact with the similar "imprinted template" of the subject supramolecular of human in the human body. In other words, the group of toxic components of Chinese materia medica can be identified with the corresponding hole channels in the body, which is the supramolecular chemical mechanism of the toxicity of Chinese materia medica. The dose-effect problem and detoxification treatment of toxic Chinese materia medica is closely related to the equilibrium constant and concentration. When the concentration of the drug with the same (similar to) imprinted template is the same, the toxicity depends on the equilibrium constant of its interaction with the target. Based on this, research idea of equilibrium constant of toxicity of Chinese materia medica was proposed. The equilibrium constant of supramolecular imprinted behavior can explain the toxicity of Chinese materia medica. By studying the equilibrium constant, the supramolecular interaction of the toxic effect can be revealed and the supramolecular system of Chinese materia medica can be well studied.
