Study on chemical constituents of Notoginseng Radix et Rhizoma and network pharmacology of its anti-inflammatory mechanism
10.7501/j.issn.0253-2670.2020.21.018
- VernacularTitle: 三七化学成分分析及其抗炎机制的网络药理学探讨
- Author:
Hui-Ting PANG
1
Author Information
1. Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
EGFR;
Gene ontology enrichment;
Ginsenoside Rg1;
Ginsenoside Rh1;
IL-2;
KEGG analysis;
MAPK14;
Monolaurin;
Network pharmacology;
Notoginseng Radix et Rhizoma;
Panaxydol;
Pathways in cancer;
STAT3;
UPLC-Q-TOF-MS;
Β-daucosterol
- From:
Chinese Traditional and Herbal Drugs
2020;51(21):5538-5547
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the main chemical constituents of Notoginseng Radix et Rhizoma (NRR) by ultra performance liquid chromatography quadrupole-time-of-flight hybrid mass spectrometry (UPLC-Q-TOF-MS), and to study on the mechanism of NRR with multi-components, multi-targets, and multi-pathways for the treatment of inflammatory based on network pharmacology. Methods: The main chemical components in NRR were analyzed by UPLC-Q-TOF-MS. DAVID database was used to analyze gene ontology (GO) enrichment analysis and Kyoto gene and genome encyclopedia (KEGG) pathway analysis. In addition, Cytoscape 3.6.1 software was used to draw network interaction diagrams, and Image GP tool was used to draw GO bubble diagrams. Results: A total of 22 active components (ginsenoside Rh1, ginsenoside Rg1, and monolaurin) of NRR and 31 related targets (EGFR, STAT3, MAPK14) were screened. GO and KEGG pathway enrichment analysis revealed that active components of NRR acted on EGFR, STAT3, MAPK14, IL2 targets, and may regulate pathways in cancer, Cytokine-cytokine receptor Interaction, CAMs and so on. Conclusion: This study reflects the characteristics of multi-components, multi-targets, and multi-pathways of NRR in the aspect of anti-inflammatory, which may provides new ideas and methodology for further research on NRR.
