Research progress on mechanism of active components of Chinese materia medica in treatment of osteoporosis based on signaling pathway
10.7501/j.issn.0253-2670.2020.23.023
- VernacularTitle: 基于信号通路的中药有效成分治疗骨质疏松机制研究进展
- Author:
Jin-Long ZHAO
1
Author Information
1. The Second School of Clinical Medical Sciences, Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Active components;
Chinese materia medica;
Inhibition of bone resorption;
Mechanism;
Osteoporosis;
Promotion of bone formation;
Signaling pathway
- From:
Chinese Traditional and Herbal Drugs
2020;51(23):6084-6094
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a systemic skeletal disease that causes a huge medical burden on patients and society. Drug treatment is the main intervention for anti-osteoporosis, but objectively existing adverse reactions reduce the patient's compliance and affect the effect of medication. Traditional Chinese medicine has good curative effect and safety in the prevention and treatment of osteoporosis, but its mechanism of action needs to be further studied. The pathway regulates the progress of osteoporosis and is one of the main targets for osteoporosis pathological mechanism and pharmacological research. In recent years, an increasing number of studies have been made on the regulatory mechanism of osteoporosis signaling pathways by active ingredients of Chinese materia medica. Recent research results on the active components of Chinese materia medica interfering with biological signaling pathways was reviewed in this article, in order to provide ideas for new drug development, basic research, and clinical applications for osteoporosis.
