Blood-brain barrier transport of drug-loaded nanoparticle: Research advances
- Author:
Bin-Yan WANG
1
Author Information
1. Department of Pharmaceutics
- Publication Type:Journal Article
- Keywords:
Blood-brain barrier;
Central nervous system agents;
Drug carrier;
Nanoparticle
- From:
Journal of International Pharmaceutical Research
2010;37(1):40-42
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier(BBB) is the basic structure to maintain homoestasis of the central nervous system, which has protective effect on brain tissue, but prevents many drugs into the brain, resulting in the limited clinical application of these drugs. How to effectively deliver the drugs through BBB has become a key step. As a novel drug-loaded carrier, nanoparticle can carry drugs through the BBB and increase the drug concentration in the brain, so as to achieve brain targeted drug delivery. This article briefly reviews recent research advances in drug-loaded nanoparticle and the mechanism of penetrating through BBB into brain tissue.
