Progress on brain-targeting non-viral gene delivery systems
- Author:
Rong-Qin HUANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Adsorptive-mediated mechanism;
Brain-targeting system;
Gene drugs;
Non-viral vector;
Receptor-mediated mechanism
- From:
Journal of International Pharmaceutical Research
2010;37(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Brain-targeting non-viral gene delivery systems could efficiently mediate gene drugs to cross blood-brain barrier and reach the diseased regions. Many researches have demonstrated that enhanced brain accumulation and gene expression could be achieved via appropriate mechanisms such as specific ligand-receptor binding function. In this review, progress on brain-targeting non-viral gene delivery systems mainly based on receptor- and adsorptive-mediated mechanisms is reviewed.
