CC chemokine receptor 4 and its inhibitors: Research advances
- Author:
Zhao-Hui SUN
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Antagonist;
Asthma;
Autoimmne diseases;
CC;
Chemokine;
G protein coupled;
Receptor
- From:
Journal of International Pharmaceutical Research
2010;37(1):29-31
- CountryChina
- Language:Chinese
-
Abstract:
CC chemokine receptor 4 (CCR4) , a member of G protein coupled receptor family, is consisted of a polypeptide chain containing seven-transmembrane domains and expressed on various cells and tissues. CCR4 can mediate nflammatory reaction by nteracting with ts ligands such as CCL17,CCL22 and CKLF1,which especially plays an mportant role n occurrence and development of asthma, thus it could be a potential target for treating nflammatory diseases, especially for asthma. In this paper,the research progress of CCR4 and ts inhibitors is summarized.
