A new approach for exploiting microbial new strain resources for drug screening
- Author:
Cheng-Bin CUI
1
Author Information
1. Institute of Pharmacology and Toxicology
- Publication Type:Journal Article
- Keywords:
Actinomycete;
Antibiotic-resistant mutation technique;
Antifungal activity;
Antitumor activity;
Auto-mutagenesis;
Fungus;
Marine-derived microorganism;
Microorganism;
Mutagen-induced mutation;
Ribosome engineering
- From:
Journal of International Pharmaceutical Research
2010;37(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Generally absolute majority of wild-type microbial strains do not produce bioactive metabolites, resulting in large numbers of so-called 'useless strains' stocked or destroyed. These strains, however, would become a great source of bioactive meabolites if their secondary metabolism could be altered to produce diverse metabolites. We have therefore undertaken a research work on exploiting microbial new strain resources for drug screening by altering secondary metabolism of the 'useless strains' to discover bioactive metabolites. A considerable progress with expectant advantage desired has been made in the studies on marine-derived actinomycetic and fungal strains. This paper summarizes our research results including several new developments in brief.
