p38 mitogen-activated protein kinases and bone metabolism
- Author:
Xi-Yue CHENG
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
Bone metabolism;
Chondrocyte;
Osteoblast;
Osteoclast;
p38 mitogen-activated protein kinases
- From:
Journal of International Pharmaceutical Research
2010;37(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen-activated protein kinase (MAPK) s a serine/tyrosine kinase which s expressed widely and regulates various signal transduction pathways in mammalian cell. As one of the key branches of MAPK pathway, p38 MAPK signaling pathway plays an important role in various physiological and pathological processes, such as cell proliferation, differentiation, apoptosis and cell cycle regulation. In recent years, the research on p38MAPK signaling pathway in cell growth, metabolism and function of osteoclast, osteoblast and chondrocyte related to bone metabolism has attracted increasing attention. This article reviews the relationship beween p38MAPK and bone metabolism, in order to investigate the mechanism of action of p38MAPK in bone metabolism related diseases.
