The mechanism, critical technology and progress of osmotic drug delivery systems
- Author:
Kun YAN
1
Author Information
1. Institute of Pharmacology and Toxicology
- Publication Type:Journal Article
- Keywords:
Controled release systems;
Osmotic pressure;
Osmotic pumps;
Semipermeable membrane
- From:
Journal of International Pharmaceutical Research
2010;37(2):92-97
- CountryChina
- Language:Chinese
-
Abstract:
As the typical example of controlled release preparation, osmotic pump-controlled release preparation is a new technique of preparation characterized by zero order release kinetics. Osmotic pressure is the motivation for releasing drug. The release behavior of osmotically controlled release systems is independent of external pH and food, and the in vivo-in vitro correlation is good, so they have attracted wide attention at home and abroad. After years of development, with the constant innovation of the mechanism, the structure of the osmotic pump has been continuously improved, and many products have been marketed. In this article, the development history and the mechanism of osmotic pump-controlled release preparation are briefly reviewed. Based on solubility, osmotic pressure, the delivery orifice and the coating membrane, the critical factors affecting the release rate and the research progress on osmotic pump controled release preparation are mainly discussed.
