Neurokinin-1 receptor antagonists: Research advances
- Author:
Fa-Gui YUE
1
Author Information
1. Department of Medicinal Chemistry
- Publication Type:Journal Article
- Keywords:
Anxiety;
Deppression;
Neurokin in;
Neurokinin-1 receptor;
Neurokinin-1 receptor antagonists
- From:
Journal of International Pharmaceutical Research
2010;37(3):203-208
- CountryChina
- Language:Chinese
-
Abstract:
Substance P is one of the most important neurotransmitter in the nervous system. It plays an important role in the pathological process of many diseases through combineing with its receptors, for example, neurokinin-1 receptor (NKIR). The antagonists of NK1R (NK1RA) that are widely used in recent clinical treatments can not only relieve deppression and anxiety, but also have good antiemetic effects on chemotherapy-induced nausea and vomiting. In this review, the relevant study results in this field in recent years are described.
