DNA methylation inhibitors: Research advances
- Author:
Pei-Kun LI
1
Author Information
1. Department of General Surgery
- Publication Type:Journal Article
- Keywords:
Antineoplastic agents;
DNA methylation,inhibitors;
DNA methyltransferase;
Nucleosides
- From:
Journal of International Pharmaceutical Research
2010;37(3):198-202
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation, catalyzed by methyltransferases, is a normal epigenetic DNA modification approach in eukaryotic cells. However, abnormal methylation often results in the development of tumors. Decitabine, as one of the most important DNA methyltransferase inhibitors, may be useful in clinical tumor therapy through demethylating tumor suppressor genes. The relationship between DNA methylation and tumor and research advances in DNA methylation inhibitors are reviewed in this article.
