Prostacyclin signal pathway: Research advances
- Author:
Wen-Tong FANG
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Peroxisomal proliferator-activated receptors;
Prostacyclin;
Prostacyclin receptor;
Prostacyclin synthase
- From:
Journal of International Pharmaceutical Research
2010;37(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
Prostacyclin (PGI2) is a member of the prostaglandins family and the main product of arachidonic acid metabolism by cyclooxygenase and prostaglandin synthase. PGI2 mediates cellular activity through binding to G-protein coupled receptor, prostacyclin receptor, therefore leading to activation of adenylyl cyclase, accumulation of cAMP and activation of PKA. PGI2 plays an important role in vascular biology such as regulating vasodilation, platelet aggregation, vascular permeability, and vascular smooth muscle cell proliferation. At high concentrations, PGI2 is able to interact with peroxisomal proliferator-activated receptor, a class of nuclear receptors, and modulate specific cellular functions such as angiogenesis. This paper reviews the research advances in PGI2 synthesis and signal pathway.
