Macrophage colony-stimulating factor receptor and its inhibitors: Research advances
- Author:
Sheng-Qian YANG
1
Author Information
1. Institute of Pharmacology and Toxicology
- Publication Type:Journal Article
- Keywords:
c-Fms inhibitors;
Inflammation;
Neoplasms;
Receptor, macrophage colony-stimulating factor;
Tyrosine kinase
- From:
Journal of International Pharmaceutical Research
2010;37(5):340-345
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage colony-stimulating factor receptor(c-Fms),encoded by the c-fms proto-oncogene,is a member of type III receptor tyrosine kinase family. c-Fms activation by binding with its ligand plays important roles in the survival, proliferation and differentiation of the monocyte-macrophage lineage and the development of embryo. Over expression of c-Fms and its ligand result in abnormalities of intracellular signaling pathways mediated by c-Fms, which is associated with tumorigenesis and inflammation. The inhibitors targeting c-Fms block intracellular signaling pathways by inhibiting c-Fms receptor tyrosine kinase are potential drugs for tumor and arthritis therapeutics.
