Structure basis of P-gp-ligands interaction and reversal of P-gp-mediated multidrug resistance
- Author:
Qing ZHAO
1
Author Information
1. Institute of Basic Medical Science
- Publication Type:Journal Article
- Keywords:
Drug efflux;
Multi-drug resistance;
P-glycoprotein;
Reversal agents
- From:
Journal of International Pharmaceutical Research
2010;37(6):439-445
- CountryChina
- Language:Chinese
-
Abstract:
P-glycoprotein(P-gp) is a multi-drug efflux transporter that plays a significant role in governing the bioavailability of various anti-cancer drugs. P-gp transporter impedes the permeability of drugs through physiological barriers resulting in limited pharmacological response. Modulation of this efflux transporter by various traditional "chemosensitizers" forms a distinctive approach in improving pharmacokinetics and conquering drug resistance. This review summarizes the recent advances in structural information of P-gp interactions with investigated ligands and new strategies to improve the poor efficiency in chemotherapy.
