Regulatory effect of transforming growth factor β on vascular remodeling
- Author:
Song CAN
1
Author Information
1. Department of Pharmacology, Anhui College of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Migration;
Phenotype traasformation;
Proliferation;
Transforming growth factor β;
Vascular adventitial fibroblasts
- From:
Journal of International Pharmaceutical Research
2012;39(5):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor β (TGF-β) is a growth factor regulating cell proliferation, differentiation and the production of extracellular matrix. Vascular remodeling is a common pathological process of many cardiovascular diseases. TGF-β can accelerate vascular adventitial fibroblasts proliferation, induce the transdifferentiation of vascular adventitial fibroblasts into myofibroblasts, and promote the vascular remodeling and a series of changes in vascular injury sites. Smad proteins involved in TGF-β intracellular signal transduction can regulate the expression of TGF-β target gene by binding with differenot proteins, so as to perform multiple biological functions. This review introduces the influence of TGF-β on the proliferation, migration and phenotype traasformation of vascular adventitial fibroblasts. © 2006 Editorial office of Foreign Medical Sciences.
