Applications of viral nanoparticles in drug delivery
- Author:
Xiang-Yang XIE
1
Author Information
1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Drug delivery;
Nanoparticle carriers;
Viral nanoparticles
- From:
Journal of International Pharmaceutical Research
2013;40(1):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Viral nanoparticles (VNP) are virus-based nanoparticle carriers that can be used as a building block for novel drug carriers with a variety of properties, such as enhancing their biological compatibility and ncreasing their targeting efficiencies. By the means of chemical modification and genetic engineering, researchers are able to connect various purposes molecules to the surfaces of VNP and adjust/change the protein amino acid sequence and the amino acid residues types of capsid protein, thereby mproving the drug delivering performances of capsid protein. In this paper, we review the recent advances of VNP' applications in drug delivery, and highlight the structure, surface modification methods and drug delivery features of several plant viral nanoparticles.
