Protective effect of Qingfei Jiedu formula on mice infected with influenza virus
- Author:
Guo-Qian SUN
1
Author Information
1. Pharmacology Laboratory, Henan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Influenza virus;
Qingfei Jiedu formula;
Viral pneumonia
- From:
Journal of International Pharmaceutical Research
2013;40(1):53-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective and treatment effect of Qingfei Jiedu formula on mice infected with influenza virus. Methods The mice were randomly divided into six groups: normal group, model group, positive drug-treated group, Qingfei Jie uformula-treate groups (3 iferentconcentrations). Intranasal infection with influenza virus was use to establish the model. Treatment was provided once a day for 6 days and the first was at 2 hours after intranasal infection. To observe the protective effect of Qingfei Jiedu formula the mice were raised and observe for14 days. The mortality average of survival time protection rate of death and rate of prolonging life were determine. To observe the treatment effect of Qingfei Jiedu formula in against influenza virus infection at the third day and sixth day after virus infection, the lung index, lung virus titer and lung tissue viral load were taken for evaluation. Results Compared with the model group, in 2. 5 and 1. 25 g/kg Qingfei Jiedu formula treated groups, the mortality significantly reduced the protection rate of death and the rate of prolonging life increased significantly, and the average survival time prolonged significantly (P <0.01). In addition the lung index lung virus titer and lung tissue viral load decreased significantly both at the third day and sixth day after the model was set up (P < 0. 01). Conclusion Qingfei Jiedu formula has a convincing anti - influenza virus activity.
