Competitive α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid receptor antagonists: Research advances
10.13220/j.enki.jipr.2014.04.04
- Author:
Dian XIAO
1
Author Information
1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Central nervous system;
Competitive antagonists;
Receptor;
α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid
- From:
Journal of International Pharmaceutical Research
2014;41(4):407-412
- CountryChina
- Language:Chinese
-
Abstract:
α-Amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid (AMPA) receptor, a subtype of ionotropie glutamate receptors widely distributed in the central nervous system，mediates the fast excitatory neurotransmission. Meanwhile more and more evidence indicates that AMPA receptor plays an important role in synaptic plasticity as well as central sensitization, and it also has close relationships with nervous system diseases. Over stimulation of AMPA receptor would produce excitotoxicity, leading to neuronal damage and finally resulting in a multitude of nervous system diseases，such as epilepsy, amyotrophic lateral scelerosis, Parkinson's dis-ease. Competitive AMPA receptor antagonists that downregulate AMPA receptor's function are of great importance in the prevention and treatment of nervous system diseases. This article reviews the research advances of competitive AMPA receptor antagonists.
