Application of quantitative analysis of multi-components by single-marker in detection of eight components of Fufang Xueshuantong capsule
10.13220/j.cnki.jipr.2014.02.019
- Author:
Su-Yun YU
1
Author Information
1. Beijing University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Different UV wavelengths;
Fufang Xueshuantong capsule;
Quantitative analysis of multi-components by single marker(QAMS);
Relative correction factor(RCF)
- From:
Journal of International Pharmaceutical Research
2014;41(2):231-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To set up a new method - quantitative analysis of multi-components by single-marker(QAMS) to determine eight components - notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and Rd, harpagoside, cryptotanshinone and tanshinone I in Fufang Xueshuantong(FX) capsule simultaneously, and validate its accuracy and feasibility for application in preparation. Methods: FX capsule was used as the research object, notoginsenoside R1 was selected as marker under 203 nm to evaluate the quality of ginsenoside Rg1, Re and Rb1, Rd, and cryptotanshinone as marker under 270 nm to evaluate the quality of harpagoside and tanshinone I. The relative correction factors (RCF) of components were calculated. The method was validated by comparison of the quantitative results between external standard method and QAMS method. Results: No significant differences were found in the quantitative analysis of components by external standard method and QAMS method. Conclusion: It is a convenient and accurate method to determine multi-components when authentic standard substances are not available. It can be used to control the quality of FX capsule.
