Methods for target identification of bioactive compounds
10.13220/j.cnki.jipr.2014.02.008
- Author:
Lin-Lin CHEN
1
Author Information
1. Fujian University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Affinity chromatography;
Compare analysis;
Target identification
- From:
Journal of International Pharmaceutical Research
2014;41(2):172-177
- CountryChina
- Language:Chinese
-
Abstract:
Target identification of bioactive compounds is one of the key issues in chemical biology and drug discovery. With the development of science technology, a variety of methods and technologies for target identification have been reported. They can be fundamentally categorized into two approaches: the direct method based on affinity chromatography which is mainly to detect the combination of drug and targets, and the indirect one which is mainly to predict the drug target and action mechanism by physiological reaction and biochemical marker. This review aims to describe the two approaches for target identification.
