ATP-binding cassette superfamily G member 2 and uric acid metabolism: Research advances
10.13220/j.cnki.jipr.2014.02.007
- Author:
Xiang-Wei XU
1
Author Information
1. Biomedical Engineering Research Center, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
ATP-binding cassette superrfamily G member 2;
Hyperuricemia;
Single nucleotide polymorphism;
Urate transporter;
Uric acid
- From:
Journal of International Pharmaceutical Research
2014;41(2):169-171
- CountryChina
- Language:Chinese
-
Abstract:
TP-binding cassette superrfamily G member 2(ABCG2), a transporter protein localizing in cell membrane and expressing in renal tubular epithelial cell brush border side, has the function of transport uric acid. In recent years, single nucleotide polymorphism (SNP) analysis has confirmed that ABCG2 is one of the most important uric acid transporters, whose dysfunction would hinder the kidney and intestinal excretion of uric acid, then increase serum uric acid and causes gout. The review summarizes the relationship between ABCG2 transporter protein and uric acid metabolism, and the SNP affecting on uric acid metabolism.
