Targeting drug delivery system based on gonadotropin-releasing hormone analogs: Research advances
10.13220/j.cnki.jipr.2014.02.002
- Author:
Yong-Tao MA
1
Author Information
1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Endocytosis;
GnRH analogs;
Receptor-mediated;
Targeted chemotherapy
- From:
Journal of International Pharmaceutical Research
2014;41(2):140-148
- CountryChina
- Language:Chinese
-
Abstract:
Targeted chemotherapy represents a modern oncological strategy designed to specifically deliver the chemotherapeutic agents to the tumor site. Gonadotropin-releasing hormone (GnRH) receptor is over-expressed on many types of tumors, and it is present in low or non-detectable quantities in the normal tissues. Thus anti-tumor drugs are specifically delivered to tumor tissues or cells via endocytosis mediated by GnRH receptors and eventually improve its therapeutic efficiency. At present GnRH receptor targeting drug delivery system has been extensively researched, which has greatly increased the drug distribution in tumor sites and improved its stability and solubility and circumvented the development of drug resistance, extended the circulation time in vivo and decreased their peripheral toxicity. This review covers the bioconjugates containing various chemotherapeutic agents, based on GnRH analogs.
