Correlation between autophagy and type 2 diabetes: Research advances
10.13220/j.cnki.jipr.2014.03.008
- Author:
Meng-Ting HE
1
Author Information
1. Biomedical Engineering Research Center, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Autophagy signal pathway;
Pancreatic ß cell;
Type 2 diabetes
- From:
Journal of International Pharmaceutical Research
2014;41(3):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a cellular reaction to the changes of internal and external environmental pressure, and a degradation process of the material composition. Recent study has shown that autophagy is closely related to the quantity and insulin secretion of pancreatic β cell. As a self-protection mechanism, the activation and regulation of autophagy are essential for maintaining the structure and function of pancreatic β cells in type 2 diabetes. Moreover, some drugs for type 2 diabetes were found to participate in the regulation of autophagy pathway in recent studies. Thus, in this review we summarize the importance of autophagy in protecting the structure and function of pancreatic β cell, the regulation of autophagy pathway and the correlation between autophagy and drugs for type 2 diabetes.
