Cellular plasticity and tumor therapy resistance: Research advances
10.13220/j.cnki.jipr.2014.03.002
- Author:
Ya-Qiong CHEN
1
Author Information
1. Department of Pharmacology, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Cellular plasticity;
Drug resistance;
Immunotherapies
- From:
Journal of International Pharmaceutical Research
2014;41(3):268-274
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance,tumor relapse and metastasis remain the main obstacles to the success of cancer treatments. Chemotherapies,targeted therapies and immunotherapies can successfully achieve remissions in cancer patients, but durable responses are rare. Although the mechanisms of diverse therapies vary,plasticity alteration of tumor and immune cells in response to therapy-induced tumor tissue injury and inflammation contributes to the development of drug resistance. This review summarizes research progress in the adaptive phenotypic plasticity of tumor cells and immune cells during tumor progression as well as the successful combination of targeted therapy and immunotherapy in cancer treatment to tackle resistance.
