Metabolic changes detected by1H NMR spectroscopy in the hippocampus of acute brain injury rats
10.13220/j.cnki.jipr.2015.05.013
- Author:
Hong-Zhuan SU
1
Author Information
1. The 184th Hospital of PLA
- Publication Type:Journal Article
- Keywords:
1H NMR spectra;
Acute brain injury;
Disorder of neurotransmitter;
Hippocampus
- From:
Journal of International Pharmaceutical Research
2015;42(5):621-624
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the alterations of metabolic profiles by detecting changes in hippocampus1H NMR spectrin acute brain injury (ABI) rats. Methods The model of ABI was achieved by trauma, and 2 hours after modeling, the hippocampus samples were collected for NMR analysis. Results Compared to age-matched control rats, the ABI rats exhibited markedly different metabolic profiles, which showed significant changes in glutamate (P<0.01), taurine(5<0.05), myo-inositol (P< 0.05), and glutamine (P<0.05). Conclusion The metabonomics results suggest that amino acid metabolism is disordered when ABI occurs. This study provides clues for further understanding to cure ABI.
