Polyethyleneimine as targeted gene vectors: A review
10.13220/j.cnki.jipr.2015.04.009
- Author:
Xiao-Fen LIU
1
Author Information
1. Department of Immunology and Pathogenic Biology, Guangdong Pharmaceutic University
- Publication Type:Journal Article
- Keywords:
Gene delivery vector;
Polyethyleneimine;
Targeting
- From:
Journal of International Pharmaceutical Research
2015;42(4):478-487
- CountryChina
- Language:Chinese
-
Abstract:
Currently, polyethylenimine(PEI) is one of the most promising non-viral gene delivery vectors. However, high relative molecular mass PEI has obvious toxicity and is short of targeting or specificity to cells or tissues. As we know targeting or specificity is the key property of ideal gene delivery systems. Therefore, PEI should be modified to become a gene vector with targeting and low toxicity. Up to now investgations on modification of PEI for targeting effect mainly include:1.modification with endogenous ligands such as transferrin Tf RGD peptide etc 2.modification with carbohydrate such as galactose etc 3.modification with specific antibody. Of these, the specific antibody-directed PEI is anticipated to be one of promising and distinctive targeting gene delivery carriers. The present paper summarises literature on PEI as targeted gene delivery vectors.
