Regulation mechanism of depression and antidepressant drug targets
10.13220/j.cnki.jipr.2015.04.006
- Author:
Lei MU
1
Author Information
1. Chinese People Armed, Police Force Hospital of Beijing
- Publication Type:Journal Article
- Keywords:
Antidepressant drugs;
Depression;
Drug target;
Hypothalamus-pituitary-adrenal axis;
Monoamine transmitters
- From:
Journal of International Pharmaceutical Research
2015;42(4):463-466
- CountryChina
- Language:Chinese
-
Abstract:
The etiology of depression is complex, and its incidence is related to many factors, such as social factors, genetic factors, endocrine and central nervous system functions. Antidepressant treatment effect by affecting one or more factors of the depression regulation system. This paper, based on the various hypotheses on the pathogenesis of depression proposes that the depression pathogenesis may involve central monoamine neurotransmitter systems, neural nutrients, neuro-endocrine system, nervous system and the immune system, and central nervous system tissue morphology changes, and summarizes the antidepressant drug research progress.
