Protective effect of autophagy on pancreatic β cells: Research advances
10.13220/j.cnki.jipr.2015.04.004
- Author:
Ying-Zhi WU
1
Author Information
1. Biomedical Engineering Research Center, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Autophagy signaling pathway;
Diabetes mellitus;
Pancreatic β cell
- From:
Journal of International Pharmaceutical Research
2015;42(4):447-452
- CountryChina
- Language:Chinese
-
Abstract:
The development of diabetes is associated with parasecretion of insulin resulting from the mass loss and dysfunction of β-cell in pancreas. Autophagy is a process of high conservation, which can improve β-cell function impaired by inflammation, oxidative stress, and endoplasmic reticulum stress. That is beneficial to delaying the progression of diabetes. Thus, in this review we summarize the definition of autophagy, autophagy related proteins and modulation of autophagy signaling pathways, the protection of autophagy on the structure and function of β-cells, as well as autophagy in β-cells with inflammation, oxidative stress and endoplasmic reticulum stress.
