Pharmacological properties of 7-ethyl-10-hydroxy-camptothecin derivatives: Research advances
10.13220/j.cnki.jipr.2015.03.004
- Author:
Chan WU
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, The Second Military Medical University
- Publication Type:Journal Article
- Keywords:
7-ethyl-10-hydroxycamptothecin;
Antitumor;
Derivative;
Solubility
- From:
Journal of International Pharmaceutical Research
2015;42(3):310-315
- CountryChina
- Language:Chinese
-
Abstract:
7-Ethyl-10-hydroxycamptothecin (SN-38) is a prominent anticancer agent, but it is insoluble in water and the most pharmaceutically acceptable solvents, the lactone ring of SN-38 shows reversible pH-dependent hydrolysis and forms to the open lactone in alkaline condition. All of these factors limit its application in clinic, and a variety of chemical modification studies have been reported to improve the efficient use of SN-38 by improving its solubility in water and pharmaceutical solvents, stabilizing the lactone form, and altering the pharmacological properties. This paper reviews the pharmacological properties of commercial SN-38 derivatives in clinical trials or preclinical studies and their research progress.
