Pulmonary drug delivery systems and progress in their applications to lung disease treatment
10.13220/j.cnki.jipr.2015.03.001
- Author:
Yi-Guang JIN
1
Author Information
1. Department of Pharmaceutical Sciences, Institute of Radiation Medicine, Academy of Military Medical Scienes
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Lung cancer;
Pulmonary drug delivery;
Pulmonary fibrosis;
Pulmonary infection
- From:
Journal of International Pharmaceutical Research
2015;42(3):289-295
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary drug delivery systems (PDDS) have some advantages, including high drug accumulation in the lungs, no first pass effect, and rapid absorption of drugs. They have become a key way to treat lung diseases and improve the absorption of biomacromolecules. In this review, we analyze lung's physiological features, and discuss the main dosage forms of lung inhalations, their preparation methods, the evaluation methods, and the in vivo experimental methods. The applications of pulmonary drug delivery to lung diseases, including acute lung injury, pulmonary infection, pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, and lung cancer, are also discussed.
