Influence of CYP3A and MDR1 genetic polymorphisms on the pharmacokinetics of ciclosporin A
10.13220/j.cnki.jipr.2015.02.004
- Author:
Ya-Fei XU
1
Author Information
1. College of Pharmacy, Yanhian University
- Publication Type:Journal Article
- Keywords:
Ciclosporin A;
CYP3A4;
CYP3A5;
Multi-drug resistance gene 1
- From:
Journal of International Pharmaceutical Research
2015;42(2):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Ciclosporin A (CsA). an immunosuppressive macrolide antibiotics, is widely applied to prevent rejections after organ transplants. CsA is mainly transported by P-glycoprotein (P-gp) and metabolized by cytochrome P450 (CYP450) 3A.Genetic polymorphisms of CYP3A and MDRl probably influence the expressions and bioactivity of CYP3A and P-gp.and may affect the pharmacokinetics of CsA.This issue summarizes the correlation between genetic polymorphisms of CYP3A and MDRl and the pharmacokinetics of CsA to guide the rational and individualized medication.
