Anti-Ebola vaccines and nucleoside drugs: Research advances
10.13220/j.cnki.jipr.2015.02.002
- Author:
Kang LI
1
Author Information
1. Beijing YouAn Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Antiviral agents;
Ebola vaccines;
Ebola vims;
Nucleic acids
- From:
Journal of International Pharmaceutical Research
2015;42(2):135-142
- CountryChina
- Language:Chinese
-
Abstract:
Ebola vims was extremely virulent and highly transmissible and caused outbreak of severe hemorrhagic fevers with high mortality in the Africa tropical regions. Currently. Ebola epidemic raging in West Africa, antiviral vaccines and drugs have also accelerated the development process. Basing on antigen delivery methods. EBOV vaccines can be divided into three categories of technology platform, including nonreplicative viral vector-based vaccines, replicative viral vector-based vaccines and viral protein antigen-based vaccines. ChAd3-ZEBOV and VSV-EBOV are the most promising vaccines against Ebola. With the basic molecular research of Ebola virus infection deepening, polynucleotides drugs and nucleoside analogue drugs against Ebola virus are hot research topics.
