Determination methods for absolute configuration of natural products
10.13220/j.cnki.jipr.2015.06.012
- Author:
Tong-Han ZHU
1
Author Information
1. Key Laboratory of Marine Drugs of Ministry Education of China, School of Medicine and Pharmacy, Ocean University of China
- Publication Type:Journal Article
- Keywords:
Absolute configuration;
Circular dichroism;
Mosher’s method;
Natural products;
Organic synthesis;
Single-crystal X-ray diffraction
- From:
Journal of International Pharmaceutical Research
2015;42(6):773-785
- CountryChina
- Language:Chinese
-
Abstract:
The physical, chemical, biological and pharmacological properties of natural products (NP)are closely related to their absolute configurations, and the determination of the NP configurations is a great challenge for natural product chemists and has attracted widespread attention of researchers. People have summed up a variety of determination methods, such as single-crystal X-ray diffraction (XRD), Mosher" s method based on the chemical reaction with the chiral reagents and nuclear magnetic resonance NMR, circular dichroism CD and organic synthesis methods, etc. These methods have advantages and disadvantages for the determination of absolute configuration of NP with different structure characteristics. This paper reviewes the principles, advantages and limitations of these common methods.
