Brain-targeted nasal drug delivery systems for the treatment of neurodegenerative diseases
10.13220/j.cnki.jipr.2016.01.015
- Author:
Li Na DU
1
Author Information
1. Institute of Radiation Medicine, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Blood-brain barrier;
Brain targeting;
In situ-forming hydrogels;
Nasal drug delivery;
Parkinson’s disease
- From:
Journal of International Pharmaceutical Research
2016;43(1):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Incidence of neurodegenerative diseases has been increasing year by year in the current aging society which interferes the living quality of the patients severely. Pathological changes in neurodegenerative diseases appeare in central nervous system CNS . The administration route of drugs to treat neurodegenerative diseases becomes a very important scientific research field. Part of drugs may cross over blood-brain barrier BBB to CNS by oral or injection administration. But most of drugs are distributed in the other tissues and might cause adverse reactions, such as gastrointestinal side-effects and arrhythmia. Moreover, the compliance of the aging patients is poor. They cannot adhere to administer multi-dose drugs for sereral times a day. Nasal drug delivery systems could deliver drugs to brains directly by nasal-brain route, avoiding BBB with high targeting ratio, high drug availability and good patients’ compliance. The review summarizes the major types of neurodegenerative diseases and their current therapeutic methods. The important obstacles for brain-targeted drug delivery, nose-brain routes and the factors influencing nasal absorption are introduced. More importantly, the principal formulations, recent research progress and the unsolved problems of brain-targeted nasal drug delivery systems are also reviewed.
