Activity regulation mechanisms of protein phosphatase 2A and its role in Alzheimer’s disease
10.13220/j.cnki.jipr.2016.01.007
- Author:
Xue-Lian LI
1
Author Information
1. Department of Pharmacology, Xuanwu Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Protein phosphatase 2A;
Tau
- From:
Journal of International Pharmaceutical Research
2016;43(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Protein phosphatase 2APP2Ais the main serine/threonine protein phosphatase of the brain, and it is involved in many physiological and pathological processes in the cell. Particularly in the pathogenesis of Alzheimer’s diseaseAD, PP2A is closely related to the main pathological features of AD. Deregulation of PP2A enzymes correlates with increased tau phosphorylation, the formation of amyloid precursor protein, and the missing of neurons. PP2A as the target of drug development may bring new hope for the treatment of AD. This review introduces the structure and activity regulation of PP2A, and the role of PP2A in AD.
