Extraction process of active phenols from clerodendranthus spicatus
10.13220/j.cnki.jipr.2016.02.031
- Author:
Song XUE
1
Author Information
1. School of Pharmacy, Shanghai Jiaotong University
- Publication Type:Journal Article
- Keywords:
Active infraction;
Clerodendranthus spicatus;
Extraction technology;
Orthogonal test;
Phenols
- From:
Journal of International Pharmaceutical Research
2016;43(2):365-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of active phenols from Clerodendranthus spicatus (Thunb) C.Y.Wu (CS). Methods The contents of total phenols, rosmarinic acid, caffeic acid, eupatorin and the yield of extract were chosen as indexes. Five methods, including methods of alkaline water extraction, alkaline water extraction with borax, water decoction, warmimpregnation with water and reflux with alcohol were compared. The extracting conditions were optimized by the orthogonal test and the single factor experiment. Results Reflux with alcohol was found to be the best way for phenols from CS. The optimized process was selected. CS was extracted with 50% alcohol twice. The extraction time of each time was 1.5 h. The volume of 50% alcohol was 10 times that of the raw material. Conclusion The optimum process is reasonable, stable and practicable.
