Research advances in synthesis of lesinurad
10.13220/j.cnki.jipr.2016.02.015
- Author:
Hui-Min WANG
1
Author Information
1. Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
Gout;
Lesinurad;
Synthesis;
Uric acid salt transport protein 1 (URAT1)
- From:
Journal of International Pharmaceutical Research
2016;43(2):280-284
- CountryChina
- Language:Chinese
-
Abstract:
Lesinurad (RDEA 594), discovered by Ardea Biosciences, is a new drug used for the treatment of gout. RDEA594 could increase the excretion of uric acid to reduce uric acid levels by inhibiting the uric acid salt transport protein 1 (URAT1). In this essay, we summarize synthetic methods of lesinurad reported in recent years, evaluate and analyze them briefly, aiming to lay a foundation for lesinurad synthesis process to achieve industrialization.
