Endoplasmic reticulum stress and non-alcoholic fatty liver disease
10.13220/j.cnki.jipr.2016.02.008
- Author:
Si-Ming KONG
1
Author Information
1. Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
- Publication Type:Journal Article
- Keywords:
Endoplasmic reticulum stress;
Hepatocyte apoptosis;
Liver lipid accumulation;
Non-alcoholic fatty liver disease;
Steatohepatitis
- From:
Journal of International Pharmaceutical Research
2016;43(2):234-238
- CountryChina
- Language:Chinese
-
Abstract:
The“two-hit”theory which underlies the mechanism of non-alcoholic fatty liver disease (NAFLD) is difficult to explain the progress of NAFLD from liver lipid accumulation to steatohepatitis, liver fibrosis and the gradually aggravated diseases.Recently the“multiple-hit”theory emphasizes the significance of endoplasmic reticulum stress (ERS) in the progression of NAFLD. The endoplasmic reticulum is a cytoplasmic organella for protein and lipid synthesis. ERS, which can be induced by the unbalance of endoplasmic reticulum homeostasis, plays a critical role in hepatocyte lipid metabolic disorders, Apoptosis and the progression of NAFLD. In this paper, the relevance of ERS and non-alcoholic liver lipid accumulation, steatohepatitis and hepatocyte apoptosis is reviewed.
