Multiple-target agents in the therapy of Alzheimer’s disease: Research advances
10.13220/j.cnki.jipr.2016.02.004
- Author:
Xi LEI
1
Author Information
1. Guangxi Medical University
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Drug combination;
Multi-target;
Multicomponent drug
- From:
Journal of International Pharmaceutical Research
2016;43(2):205-215
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is mainly Acetyl cholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) antagonist, which are single-target AD drugs. They are limited symptomatic treatment and their efficacy remains unsatisfactory. Due to the complexity and multifactorial etiology of AD, the multi-target-directed ligand approach is a hopeful way of searching new anti-AD drugs. Here we review the advancement of multitarget AD drugs in recent years: single compound with more than one target, multicomponent drug and drug combination.
