Preformulation study of curcumenol
10.13220/j.cnki.jipr.2016.03.031
- Author:
Zhe MA
1
Author Information
1. Department of Pharmacy, Shengjing Hospital of China Medical University
- Publication Type:Journal Article
- Keywords:
Curcumenol;
Oil-water partition coefficient;
Solubility;
Stability
- From:
Journal of International Pharmaceutical Research
2016;43(3):562-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physical- chemical parameters of curcumenol so as to design its optimal preparations. Methods An HPLC method was established to determine the content of curcumenol. Based on the method, the equilibrium solubility, oil/water partition coefficient and stability of curcumenol were investigated. Results The equilibrium solubility in the pure water was 1.93 mg/ml (25 °C) and 2.6 mg/ml (37°), respectively. The oil/water partition coefficient was in the range of 2.2-3.0. Curcumenol solution was unstable at high temperature under light conditions, while pH value showed little effect. Conclusion The analytical method is accurate and reliable. The solubility of curcumenol can be described as strong lipotropic and slightly soluble in water. Nanoformulation and solubilization technologies could improve its bioavailability significantly. Curcumenol should be stored and operated in a dark and cool place.
