Synthesis and evaluation of new 3-aminooxazolidin-2-one derivatives for inhibiting bacterial quorum sensing
10.13220/j.cnki.jipr.2016.03.014
- Author:
Shan-Chao ZENG
1
Author Information
1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
3-aminooxazolidin-2-one;
Bacterial quorum sensing;
Inhibitory activity
- From:
Journal of International Pharmaceutical Research
2016;43(3):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop some 3-aminooxazolidin-2-one derivatives with bacteria quorum sensing(QS) inhibitory activity. Methods Using (2-hydroxyethyl) hydrazine as raw material, we finished the synthesis through cyclization, condensation, hydrolysis and condensation reaction, and evaluated their inhibition of QS via Chromobacterium violaceum. Results Eight compounds were synthesized and their structures were confirmed by 1H NMR and MS characterization. Compounds Z2 had inhibitory effect against QS. Conclusion None of the eight synthesized compounds have been reported before and the synthetic route is reliable. Compounds Z2 have inhibitory effect against QS.
