Advances in particle engineering techniques for pulmonary drug delivery
10.13220/j.cnki.jipr.2016.03.010
- Author:
Xi CHEN
1
Author Information
1. Department of Pharmaceutical Science, Sichuan Nursing Vocational College
- Publication Type:Journal Article
- Keywords:
Freeze drying;
Micronization, controlled crystallization;
Particle engineering techniques;
Pulmonary drug delivery;
Spray drying;
Supercritical fluid
- From:
Journal of International Pharmaceutical Research
2016;43(3):455-460
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, pulmonary drug delivery as an attractive non-invasive administration way has been gaining intensive attention. The market for inhalable therapy has constantly grown over past years. Various particle engineering techniques have been employed to exploit the drug particles or drug-loaded particles used for pulmonary delivery with suitable physical properties. Those tailor-made inhalable particles offer the possibility of efficient delivering to lungs and the most optimal therapeutic outcomes. This review highlights the deposition mechanism of particles in lungs and several particle engineering techniques for pulmonary drug delivery, in particular two novel techniques PulmoSphere™ and TechnoSphere™, which have been used in the marketed products.
