Synthesis of isavuconazonium sulfate: Research advances
10.13220/j.cnki.jipr.2016.03.006
- Author:
Hai-Chao SONG
1
Author Information
1. Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
Antifungal agent;
Isavuconazole;
Isavuconazonium sulfate;
Pharmaceutical chemistry;
Synthesis;
Water-soluble segments of side chain
- From:
Journal of International Pharmaceutical Research
2016;43(3):436-440
- CountryChina
- Language:Chinese
-
Abstract:
Isavuconazole is a broad-spectrum triazole antifungal agent, which is administered as a water-soluble prodrug-isavuconazonium sulfate. Recently, its oral and intravenous formulations are available. Isavuconazole inhibits fungal cytochrome P45014DM, thus interferes with the biological function of cell wall formation and plays the antifungal role. In this paper, we summarize the synthetic methods of isavuconazole, water-soluble segments of side chain and isavuconazonium sulfate and evaluate their advantages and disadvantages, which lays a foundation for isavuconazonium sulfate technology development.
