Optimization of artemether self-microemulsifying drug delivery system by central composite design-response surface methodology
10.13220/j.cnki.jipr.2016.05.030
- Author:
Xia TIAN
1
Author Information
1. Yunnan Institute of Materia Medica, Yunnan Bai Yao Group Innovation R&D Center, Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation
- Publication Type:Journal Article
- Keywords:
Artemether;
Response surface methodology;
Self-microemulsifying;
Star point design;
Ternary phase diagram
- From:
Journal of International Pharmaceutical Research
2016;43(5):966-970
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize and assess the formulation of self-microemulsifying drug delivery systems (SMEDDS) for artemether(ARM). Methods The optimized formulation of ARM-SMEDDS was screened by solubility, ternary phase diagram and central composite design-response surface methodology, with the particle size, Zeta potential and solubility as parameters. The physicochemical property and dissolution characters of ARM-SMEDDS were also determined. Results The optimized SMEDDS was composed of Cremophor RH40 (39.29%), Transcutol HP (35.71%) and MCT(25%). The average particle size after the emulsification was 24.52 nm, the Zeta potential was-10.10 mV, and the drug loading of self-microemulsifying exceeded 88 mg/g. Conclusion The optimized formulation of ARM-SMEDDS using the star point design-response surface methodology has significantly enhanced the solubility and in vitro dissolution of ARM.
