New drugs for gont: Research advances
10.13220/j.cnki.jipr.2016.05.009
- Author:
Cai-Xia TU
1
Author Information
1. Biomedical Engineering Research Center, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Gout;
Hyperuricemia;
Uric acid transporter;
Uricase;
Xanthine oxidoreductase
- From:
Journal of International Pharmaceutical Research
2016;43(5):858-862
- CountryChina
- Language:Chinese
-
Abstract:
Gout is a common disease in the elderly men. The prevalence rate of gout is rising worldwide in recent years, and gout has become a serious metabolic disease threatening human health. Moreover, gout is also closely related to incidence of many diseases and symptoms such as hypertension, hyperlipidemia, atherosclerosis, obesity and insulin resistance. Recently, investigation and development of new drugs have attracted increasing attention. This paper summarizes the research advances in new agents for treatment of gout, including the uric acid reduction drugs that target the key enzymes of purine metabolism, the drugs which target the renal tubular urate transporters to lower the uric acid level, the dual inhibitors of xanthine oxidoreductase(XOR) and renal tubular urate transporters, and the uricase.
