Techniques for molecular network construction in network pharmacology study
10.13220/j.cnki.jipr.2016.05.001
- Author:
Wen-Xia ZHOU
1
Author Information
1. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
Diseaseome network;
Drugome network;
Molecular interactome network;
Network construction;
Network pharmacology;
Network visualization
- From:
Journal of International Pharmaceutical Research
2016;43(5):797-812
- CountryChina
- Language:Chinese
-
Abstract:
Network construction technology is the basis for network pharmacology research. Data originated from experiment, database and computational prediction can be used to construct drugome network, diseaseome network and molecular interactome network. The molecular network construction for the complex diseases represented by Alzheimer′s disease (AD) could be used to identify the important targets, pathogenesis and drug action mechanism, and guide drug development and drug reposition. This paper reviews techniques for molecular network construction in network pharmacology study.
