Preparation of lansoprazole biphasic release pellet capsules
10.13220/j.cnki.jipr.2016.06.019
- Author:
Shu-Xiang YU
1
Author Information
1. Lianyungang Jari Pharmaceutical Co., Ltd
- Publication Type:Journal Article
- Keywords:
Biphasic release;
Centrifugal granulation;
Enteric-coated pellets;
Enteric-coated pulse pellets;
Lansoprazole
- From:
Journal of International Pharmaceutical Research
2016;43(6):1129-1134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare lansoprazole biphasic release pellet capsules. Methods The pellets carrying lansoprazole were directly prepared by centrifugal making-pill method, and the pellets of enteric coating and enteric pulsatile coating were adopted by fluidized bed coating method. Then the two kinds of pellets were filled by a fixed proportion to hollow capsules. In vitro dissolution method was used for the observation of the drug release behavior. Results The optimized formulation was as follows: the magnesium carbonate level was 15%, the L-HPC level was 20% in pellets carried drug, the isolation gown level was 9%-10%, the enteric coating level was above 41% in enteric coated pellets, the swelling agent level was 50-60%, the controlled layer level was 50%, the enteric coating level was above 41% in pulsatile enteric coated pellets, and the drying time was 4 h in the end. Conclusion The method is feasible for preparation of lansoprazole biphasic release pellet capsules by encapsulating enteric-coated pellets, and able to obtain good repeatability and stable quality.
