Human protein tyrosine phosphatase β and its inhibitors: Research advances
10.13220/j.cnki.jipr.2016.06.005
- Author:
Chong-Yi AI
1
Author Information
1. Institute of Pharmaclology and Toxicology, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
HPTPβ;
Inhibitor;
Protein tyrosine phosphatase
- From:
Journal of International Pharmaceutical Research
2016;43(6):1049-1053
- CountryChina
- Language:Chinese
-
Abstract:
Human protein tyrosine phosphatase β (HPTPβ) is an endothelial cell-specific receptor protein tyrosine phosphatase(PTP). HPTPβ plays an important role in regulating pathophysiological processes such as angiogenesis and cell-to-cell adherens junction, and is taken as a novel target for developing new antiatherosclerosis and antitumor drugs. In this review, the latest research progress in the structure, physiological functions and small molecular inhibitors of HPTPβ is summarized.
