Molecular genetic studies of skeletal dysplasia: Research advances
10.13220/j.cnki.jipr.2017.02.017
- Author:
Jia-Chen LIN
1
Author Information
1. Department of Orthopedic Surgery
- Publication Type:Journal Article
- Keywords:
Genetic skeletal disorders;
Molecular diagnosis;
Pathogenic mutations;
Skeletal dysplasia;
Whole exome sequencing
- From:
Journal of International Pharmaceutical Research
2017;44(2):178-189
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal dysplasia(SD)is a group of genetic disorders resulting from disruption of normal skeletal growth and development, characterized by heterogeneous and overlapping phenotypes. Molecular diagnosis is required to help physicians further identify the type, etiology and prognosis of the disease. A great number of discoveries of pathogenic mutations has been made largely due to extensive use of whole exome sequencing(WES)and the genomic technique. Here we review the most recent molecular genetic studies of SD using WES technique.
