Novel preparation techniques used in new dosage form of dipyridamole:research advances
10.13220/j.cnki.jipr.2018.04.002
- Author:
Xia TIAN
1
Author Information
1. Yunnan Institute of Materia Medica, Yunnan Bai Yao Group Innovation R&D Center, Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation
- Publication Type:Journal Article
- Keywords:
Dipyridamole;
Dosage form;
Gastro-floating;
Microenvironmental pH;
Solid dispersion
- From:
Journal of International Pharmaceutical Research
2018;45(4):253-257
- CountryChina
- Language:Chinese
-
Abstract:
Dipyridamole,a widely used drug in clinics that inhibits platelet agregation,also shows great potential for anti-vi- ral and anti-tumor effect in recent years. However,with its poor and pH-dependent solubility as well as the narrow absorption window in the gastrointestinal tract,the conventional oral dosage forms have problems of low bioavailability,high inter-subject variability and insufficient drug efficacy. The novel drug delivery systems based on solid dispersion,gastro-floating,microenvironmental pH-modifica- tion,drug-protein complex and nanoparticle technologies are the effective methods to enhance oral drug absorption. In this paper we re- view the recent advances in novel dosage form and preparation technology of dipyridamole,to provide references for development of novel preparation with good safety,therapeutic efficacy and patient compliance.
